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eBook details

• Title: Conversion from Epoetin Alfa to Darbepoetin Alfa Within the Manitoba Renal Program: Evaluation of Dose Ratios.
• Author : CANNT Journal
• Release Date : January 01, 2008
• Genre: Industries & Professions,Books,Business & Personal Finance,
• Pages : * pages
• Size : 274 KB

Description

Introduction Anemia is a frequent complication of chronic kidney disease (CKD), and its management typically includes the use of erythropoietic agents. Erythropoietic therapies have been shown to improve hemoglobin concentrations, reduce transfusion requirements, provide cardioprotection through regression of left ventricular hypertrophy and improve quality of life (Pisoni, Bragg-Gresham, Young, Akizawa, Asano, Locatelli et al., 2004; Locatelli, Canaud, Giacardy, Martin-Malo, Baker, & Wilson, 2003). Currently, available agents in Canada include epoetin alfa and darbepoetin alfa. Advantages of darbepoetin alfa as compared to epoetin alfa include less frequent administration and similar routes with subcutaneous (SC) and intravenous (IV) dosing (Egrie & Browne, 2001; Macdougall, Gray, Elston, Breen, Jenkins, Browne, & Egrie, 1999).

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